TAILORED TETRAVALENT ANTIBODIES POTENTLY AND SPECIFICALLY ACTIVATE WNT/FRIZZLED PATHWAYS IN CELLS, ORGANOIDS AND MICE

Tailored tetravalent antibodies potently and specifically activate Wnt/Frizzled pathways in cells, organoids and mice

Secreted Wnt proteins regulate development and adult tissue homeostasis by binding and activating cell-surface Frizzled receptors and co-receptors including LRP5/6.The hydrophobicity of Wnt proteins has complicated their purification and limited their use in basic research and as therapeutics.We describe modular tetravalent antibodies that can recr

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Overexpression of Optic Atrophy Type 1 Protects Retinal Ganglion Cells and Upregulates Parkin Expression in Experimental Glaucoma

Glaucoma is a neurodegenerative disease that features progressive loss of retinal ganglion cells (RGCs).Increasing evidences have revealed that impaired mitochondrial dynamics occurs early in neurodegenerative diseases.Optic Atrophy Type 1 (OPA1), a mitochondrial fusion protein, has recently been suggested to Asciugamani lavabili o monouso be a mit

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